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Production:

The preparation method uses acetylsalicylic chloride as raw material, reacts with diethyl malonate in acetonitrile solvent in the presence of magnesium chloride, adds triethylamine, and reacts at 0°C for 1 hour to obtain (2-acetoxybenzene) The product of diethyl formyl)malonate is then heated to 50°C in a potassium hydroxide/methanol solution, reacted for 3h, and cyclized to obtain the product. Ethyl acetoacetate can also be used as a raw material, in the presence of sodium hydroxide, in isobutyl methyl ketone solvent with acetylsalicylic chloride at 15-20 ℃ for 3.5h to obtain 365bet娱乐book to 2-(2-hydroxybenzoyl ) Sodium acetoacetate, the reaction product is reacted with hydrochloric acid at 25-30°C for 30 minutes to obtain 3-acetyl-4-hydroxycoumarin, and then heated at 90-95°C under concentrated sulfuric acid for 4 hours to obtain the product. You can also use 2-hydroxyacetophenone as a raw material, in the presence of potassium carbonate, pass 5.88MPa carbon dioxide into the autoclave, let it pass for 15h at room temperature, and then keep it at 60℃ for 15h, firstly produce 2-hydroxybenzene-3- Oxypropionic acid, and then cyclic synthesis product.

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