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This year's Nobel Prize in Chemistry was announced at 17:45 on October 5 at the Royal Swedish Academy of?

Sciences in Stockholm, Sweden. The Nobel Prize Committee awarded this year's Nobel Prize in Chemistry to American scientist Carolyn R. Bertozzi, Danish scientist Morten Meldal and American scientist Carolyn R. Bertozzi. K. Barry Sharpless, for "for the development of click chemistry and bioorthogonal chemistry", which aims to make difficult processes easier .

• Reason for award

For a long time, drug molecules, leads, drug candidates, biological probes, applied materials and complex molecules with special functions have attracted extensive research interests of scientists, but their construction process is often plagued by problems such as time-consuming and expensive reagents many scientists.?This year's Nobel chemists have developed a fundamental technology aimed at creating a variety of functional molecules, simplifying the synthesis of complex molecules and even building functional molecules through a straightforward route。

Morten Meldal and? K. Barry Sharpless have developed a basic technology, click chemistry , which enables the direct synthesis of various complex functional molecules (drug candidate compounds, biological probes, applied materials, etc.). Carolyn R. Bertozzi? took click chemistry to a new dimension and used it in living organisms to study sugar chains on the surface of cells and play an important role in cancer, infectious diseases, inflammatory diseases, etc., and highlighted some A chemical biological study of the function of sugar chains at the molecular level.

In-depth analysis

Around 2000, K. Barry Sharpless proposed the concept of "click chemistry ", which is generally simple and quick to click the button, and obtains various biological diversity molecules, such as drug candidate compounds, through highly selective and efficient reactions of functional groups. , biological probes, applied materials, etc.

Soon after, Morten Meldal and K. Barry Sharpless independently reported on today's crown jewel of click chemistry: copper-catalyzed azide cycloaddition to alkynes . This method is an elegant and efficient chemical reaction and has been widely used in drug development, DNA mapping, and the synthesis of biological probes and other functional materials.

Carolyn R. Bertozzi? took click chemistry to a new dimension and used it in living organisms to study sugar chains on the surface of cells and play an important role in cancer, infectious diseases, inflammatory diseases, etc. , And focus on the chemical biology research on the functions of sugar chains at the molecular level.