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Name:(S)-1-Boc-3-hydroxypiperidine    

CAS NO:  143900-44-1

Purity: 98% min

MF: C10H19NO3

MW:201.263

BP:292.3±33.0 °C at 760 mmHg

Density:1.1±0.1 g/cm3

MP: 34-40?C

EINECS:N/A

Appearance:white powder 

Package: 25g, 100g, 500g, bulk package

Application:Pharmaceutical Intermediates

Other name:

1-Piperidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3S)-;

(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine;

2-Methyl-2-propanyl 3-hydroxy-1-piperidinecarboxylate;

tert-Butyl-(3S)-3-hydroxypiperidin-1-carboxylat;

(S)-1-Boc-3-piperidinol;

(S)-N-Boc-3-hydroxy piperidine;

(S)-3-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester;

1,1-dimethylethyl (3S)-3-hydroxypiperidine-1-carboxylate;

(S)-N-Boc-3-hydroxypiperidine (S-NBHP)CAS NO:  143900-44-1  is a critical chiral intermediate in the synthesis of pharmaceuticals, including ibrutinib, the active pharmaceutical ingredient of the new drug Imbruvica approv.

(S) -N-Boc-3-hydroxypiperidine (S-NBHP) CAS NO:  143900-44-1 is a useful synthon for the synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma. To our knowledge, there are no published biotransformation methods scalable to prepare S-NBHP. We report here the development of an efficient process catalyzed by recombinant ketoreductase (KRED) to reduce N-Boc-piperidin-3-one to obtain optically pure S-NBHP. The process has been optimized and demonstrated to have commercial potential with 100 g/L of substrate concentration, product of >99% ee with under 5% of enzyme loading (w/w).

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