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Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) is a synthetic derivative of pyridine. 

Pirfenidone has been used:

? as a post-operative eye drop in rabbits to analyse its antifibrotic effect to improve glaucoma filtration surgery

? as an anti-scarring agent to examine whether it affects the foreign body reaction after glaucoma drainage device (GDD) implantation in a rabbit

? to test its antifibrotic potential in primary cultures of human orbital fibroblasts (hOFs)

? as tumor necrosis factor (TNFα) inhibitor to study its effect in hypoxia

Product Details:                             

Name: Pirfenidone

Synonyms: 

amr-69;

TORASEMIDETECHPIRFENIDONE;

5-methyl-1-phenyl-1H-pyridin-2-one;

5-Methyl-1-phenyl-2-(1H)-pyridone;

5-methyl-1-phenyl-pyridin-2-one;

5-methyl-1-phenyl-2(1H)-pyridinone

CAS: 53179-13-8

EINECS: 621-260-7

MF: C12H11NO

MW: 185.22200

MP: 96-97?C

BP: 329.1?C at 760 mmHg

FP: 152.7?C

Density: 1.137 g/cm3

Purity: 98%

Appearance: Off-white solid

Solubility: DMSO: ≥10 mg/mL, soluble

Package: 5g, 25g, 100g, 500g, 1kg, 25kg

Storage Condition: Store at RT

Application: Pirfenidone is used to treat idiopathic pulmonary fibrosis (IPF). It helps to decrease the weakening of lung function decline and ameliorate progression-free survival. Pirfenidone can repress the multiplication and contraction of collagen of human tenon’s fibroblasts.

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