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Name: NVP-BKM120 (Hydrochloride)   

CAS NO: 1312445-63-8

EINECS:N/A

MF: C18H22ClF3N6O2

MW: 446.854

MP: N/A

BP:N/A

Density:N/A

Appearance: White soild powder

Purity: >98%

Package: 25g, 100g, 500g, bulk package 

Application:Pharmaceutical intermediate

Other name:

2-Pyridinamine, 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-, hydrochloride (1:1);

5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine hydrochloride (1:1);

Buparlisib hydrochloride [USAN];

BKM 120 hydrochloride;

Buparlisib HCl;

Description:

A potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively; much less effectively inhibits the class III PI3K Vps34 and mTOR, and has no effect on PI4Kβ and several other kinases; prevents the growth of assorted cancer cell lines when used at 5 μM and inhibits tumor growth in vivo.Blood CancerPhase 2 Clinical.

Note: Products for research use only, not for human use.

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