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Name:Nigericin

Other name: NIGERICIN SODIUM SALT;

Nigericin sodium;

(2R)-2-((3S)-6-{[2-((5S)-5-{(3S)-5-[(3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethylperhydro-2H-pyran-2-yl]-3-methyloxolan-2-yl}-5-methyloxolan-2-yl)(2S,4R,9R,10R)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methylperhydro-2H-pyran-2-yl)propanoic acid;

2H-Pyran-2-acetic acid, tetrahydro-6-[[(2S,4R,5R,9R,10R)-9-methoxy-2,4,

10-trimethyl-2-[(2S,3'R)-octahydro-2,3'-dimethyl-5'-[(3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-1,6-dioxaspiro[4.5]dec-7-yl]methyl]-α,3-dimethyl-, sodium salt, (αS,3R)- (1:1);

(2R)-2-[(2R,3S,6R)-6-{[(2S,4R,5R,7R,9R,10R)-2-{(2S,2'R,3'S,5R,5'R)-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methyltetrahydro-2H-pyran-2-yl]propanoic acid;

CAS: 28380-24-7

EINECS:N/A

MF: C40H67NaO11

MW: 746.943

MP: 245-255?C

Appearance: White solid

Purity: 98% min

Package: 25g, 100g, 500g, bulk package 

Application: Intermediate for pharmaceuticals

Water Solubility: Miscible

Nigericin CAS:28380-24-7 is a compounds of polycyclic ether carboxylic acid,the main role is to hydrogen ion and potassium ion exchange similar jie ammonia enzyme and potassium ions to form complexes, it negatively charged carboxylate interact with cationic formation of cephalosporins in Nigeria - potassium ion complexes, hydrogen ion and potassium ion exchange.

Nigericin CAS:28380-24-7 a polyether antibiotic derived from streptomycetes, is also an ion carrier with high affinity to cations such as Na+/K+, which can destroy membrane potential in mitochondria and golgi bodies. Nigerian mycetin has good biological inhibitory activity against gram-positive fungal tumors and viruses such as HIV.

Nigericin is an antibiotic derived from Streptomyces hygroscopicus. Its isolation was described in the 1950s, and in 1968 the structure could be elucidated by X-ray crystallography. The structure and properties of nigericin are similar to the antibiotic monensin. Commercially it is obtained as a byproduct, or contaminant, at the fermentation of Geldanamycin. It is also called Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464. Nigericin acts as an H+, K+, Pb2+ ionophore. Most commonly it is an antiporter of H+ and K+. In the past nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions in Eukaryotic cells. Nigericin exhibits anticancer and anti-HIV activity.

Nigericin CAS:28380-24-7 the storage condition is 2-8?C.

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