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Description of N-methylnicotinate CAS No.: 535-83-1

 

Name: N-methylnicotinate

CAS No.: 535-83-1

EINECS MO：208-620-5

Formula: C7H7NO2

Molecular Weight: 137.14  

Melting Point:260ºC (dec.)

BP:251.96°C (rough estimate)

Density: 1.2528 (rough estimate)

Appearance: Off-White to Light Beige Solid

Package: 25g, 100g, 500g, bulk package

Application:Fine chemical intermediates

 

 

Trigonelline CAS No.: 535-83-1 is primarily synthesized from nicotinic acid in plants. The biosynthesis involves the methylation of nicotinic acid, a process catalyzed by N-methyltransferase enzymes.

 

Trigonelline CAS No.: 535-83-1 is a natural compound found in plants belonging to the family of Fabaceae. It has been shown to be a potent activator of Toll-like receptor 4 (TLR4) and induces an inflammatory response in biological samples, such as macrophage cells. Trigonelline also has anti-inflammatory properties and has been shown to inhibit neuronal death. The hypoglycemic effect of trigonelline may be due to its inhibition of glucose uptake by cells. Furthermore, trigonelline has been shown to act as an antioxidant and regulate energy metabolism through the action of mitochondria. Trigonelline also acts as a matrix metalloproteinase inhibitor, which may provide therapeutic benefits for osteoarthritis and other diseases resulting from joint degradation. Trigonelline can be extracted from plants by chromatographic analysis or purified from plant material using analytical methods such as high performance liquid chromatography (HPLC).

 

 

Other name or Synonyms:

 

Betain nicotinate;

Coffearine;

N-methyl-3-carboxypyridinium;

1-methylpyridinium-3-carbonate;

Trigonellin;

Trigenolline;

Gynesis;

Coffearin;

1-methyl-3-pyridinium carboxylate;

TRIGONELLINE;

Gynesine;

Pyridinium, 3-carboxy-1-methyl-, hydroxide, inner salt;

Caffearine;

 

 

Description of N-methylnicotinate  CAS No.: 535-83-1

 

Trigonelline is an alkaloid with chemical formula C7H7NO2. It is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3). Trigonelline is a product of niacin metabolism that is excreted in urine of mammals.
Trigonelline occurs in many plants. It has been isolated from fenugreek seeds (Trigonella foenum-graecum, hence the name), garden peas, hemp seed, oats, potatoes, Stachys species, dahlia, Strophanthus species, and Dichapetalum cymosum. Trigonelline is also found in coffee. Higher levels of trigonelline is found in arabica coffee.

Application of N-methylnicotinate CAS No.: 535-83-1

 

1. Neurological Disorders Treatment
Application Summary : Trigonelline, a naturally occurring alkaloid found in various plants, has emerged as a potential treatment option for diverse neurological disorders. It's involved in several pathways like Oxidative Stress and Antioxidant, Inflammatory, Neuroprotection and Neurotrophic, Mitochondrial Function and Energy Metabolism.

2. Allergic Asthma Treatment
Application Summary : Trigonelline, one of the active compounds from Leonurus japonicus Houtt., has been proven to have pharmacological value in diabetes, the central nervous system and cardiovascular diseases. Recent studies have shown that it may also be beneficial in controlling inflammation.

3.Mitochondrial Dysfunction Treatment
Application Summary : Trigonelline, a natural alkaloid, has been found to be a therapeutic agent for mitochondrial dysfunction observed in sarcopenia and during the aging of skeletal muscles .

4.Cognitive Function Improvement
The research indicates that Trigonelline modifies key molecular pathways and reduces neuroinflammation, highlighting its potential in addressing age-related cognitive decline . It was found that Trigonelline improves spatial learning and memory by inhibiting neuroinflammation and restoring neurotransmitter levels in the brain

5. Anti-Cancer
Application Summary : Preliminary research indicates that Trigonelline may possess anticancer capabilities. It seems to inhibit the growth of certain cancer cell lines .

6. Heart Health
Application Summary : By influencing lipid metabolism and reducing inflammation, Trigonelline might play a role in heart health .

 

Future Directions

Trigonelline has emerged as a potential treatment option for diverse neurological disorders . It has also been reported to improve cognitive function and shows potential in alleviating age-related impairment . Further experimental validation and preclinical studies are warranted to confirm the efficacy and safety of trigonelline as a potential treatment option .

 

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