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Description of HBTU CAS：94790-37-1

 

Name: HBTU  

CAS NO: 94790-37-1

EINECS:423-020-5

MF: C11H16F6N5OP

MW: 379.24

MP: 200 °C (dec.)(lit.)

Appearance: White Powder

Purity: 99% min

Package: 25g, 100g, 500g, bulk package

Application:Pharmaceutical Intermediates

 

 

Other name:

N-[(1H-1,2,3-Benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methylmethanaminium hexafluorophosphate;

Methanaminium, N-[(1H-1,2,3-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methyl-, hexafluorophosphate;

N,N,N′,N′-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate;

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;

N-[(1H-Benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methylmethanaminium hexafluorophosphate;

(1H-Benzotriazol-1-yloxy)(dimethylamino)-N,N-dimethylmethaniminium hexafluorophosphate;

[benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium,hexafluorophosphate;

 

Application of HBTU CAS：94790-37-1

 

HBTU is a chemical compound widely used in organic synthesis, particularly in peptide coupling reactions. It is known for its efficiency in forming peptide bonds with minimal racemization, making it a valuable reagent in the field of peptide synthesis .

Key Applications of HBTU

Peptide Synthesis :
This compound is predominantly used in solid-phase peptide synthesis (SPPS), where it facilitates the coupling of amino acids to form peptides with high yields and minimal side reactions.
It has shown effectiveness in synthesizing complex peptides, including cyclic and branched structures.

Synthesis of Quinoxaline Derivatives :
This compound acts as a Lewis acid catalyst in the synthesis of quinoxaline derivatives, providing a mild and efficient protocol for this transformation .

Conversion of Carboxylic Acids :
The reagent promotes the conversion of carboxylic acids into benzimidazoles through a one-pot strategy, demonstrating its utility in diverse organic transformations .

Synthesis of Glycoconjugates :
This compound is employed in the synthesis of malonyl-linked glycoconjugates, showcasing its efficiency compared to other coupling reagents .

 

Drug Delivery Systems :
In liposome-based drug delivery systems, this compound is utilized to couple phospholipids with therapeutic agents, enhancing the efficacy and targeting capabilities of drug formulations

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