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Production Introduction

Name:Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

CAS:141942-85-0

MF:C7H11NO3

MW:157.17

EINECS:430-220-6

BP:270 °C

MP:N/A

FP: >230 °C

Purity:97%min.

form :Liquid

color :Colorless to yellow

Package:1g,5g,25g

Storage condition:2-8°C

Density:1.114 g/mL at 25 °C

Application:Pharmaceutical intermediates

Description:  

1. Atorvastatin Intermediate

2. analgesic, antipyretic, and anti-inflammatory

3. (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.

Applicatio苍：

Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

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