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Name: Entrectinib  

CAS NO: 1108743-60-7

EINECS:N/A

MF: C31H34F2N6O2

MW: 560.638

MP: N/A

BP:717.5±60.0 °C at 760 mmHg

Density:1.3±0.1 g/cm3

Appearance: White powder

Purity: 98% min

Package: 25g, 100g, 500g, bulk package

Application:Pharmaceutical intermediate

Other name:

N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide;

Benzamide, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]-;

RXDX101;

Description

Entrectinib CAS NO: 1108743-60-7 also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. RXDX-101 has demonstrated potent pharmacological activity in preclinical studies and has the potential to be first-in-class against the Trk family of kinases. PXDX-101 has been well tolerated in patients with advanced solid tumors.

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