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Name: Chloroquine  

CAS NO: 54-05-7

Purity: 99%

MF: C18H26ClN3

MW:319.872

BP:460.6±40.0 °C at 760 mmHg

Density:1.1±0.1 g/cm3

MP: 87?C

EINECS:200-191-2

Appearance: White Powder

Package: 25g, 100g, 500g, bulk package

Application: Pharmaceutical intermediate

Other name:

Bemaco;

N-(7-Chloro-4-quinolinyl)-N,N-diethyl-1,4-pentanediamine;

[3H]-Chloroquine;

N-(7-Chloroquinolin-4-yl)-N,N-diethylpentane-1,4-diamine;

1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-;

N4-(7-Chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine;

Amokin;

Indications

Chloroquine is used to treat chloroquine-sensitive falciparum malaria, vivax malaria and three-day malaria. It can also be used for the inhibitory prevention of malaria symptoms. Can also be used for the treatment of parenteral amebiasis, paragonimiasis, clonorchiasis; connective tissue diseases such as discoid lupus erythematosus, SLE with skin lesions and joint lesions, rheumatoid arthritis, Sjogren's syndrome, light Sensitive diseases such as sunburn and erythema.

This product can kill the malaria parasites in various developmental stages of red blood cells, and has a fast, strong and long-lasting effect on erythrocyte intracellular schizonts. It is ineffective against extra-erythrocytic parasites and cannot prevent recurrence and cure vivax malaria; falciparum malaria has no extraerythrocytic phase and can be cured.

Chloroquine is an antimalarial drug. It mainly plays a role in the red internal phase of the malaria parasite, and can effectively control the onset of malaria symptoms. No effect on the infrared phase, can not prevent recurrence, but because of the longer lasting effect, it can delay the recurrence, because the falciparum malaria has no infrared phase, and can cure. It is ineffective in the early red stage and has no direct effect on the gametophyte, so it cannot be used as a cause. However, since the resistance of Plasmodium falciparum to chloroquine in the 1960s, the practical value of chloroquine began to decline, and it has been replaced by other new scleroside drugs in the chloroquine-resistant falciparum malaria area. In addition to anti-malarial, chloroquine can also be used for the treatment of hepatic amebiasis, clonorchiasis, paragonimiasis, connective tissue disease and the like.

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