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CAS: 434-16-2 7-Dehydrocholesterol
A vitamin precursor.
Vitamin D3 is produced by the action of sunlight or ultraviolet irradiation from the precursor, 7-dehydrocholesterol (7-DC), that is synthesized in the skin of animals and humans.
In most tissues of the body, 7-dehydrocholesterol is the immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3¦Â-hydroxysterol-¦¤7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS. 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944. 7-DHC is a provitamin that is converted to vitamin D3 by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.
SPECIFICATION OF CAS: 434-16-2 7-Dehydrocholesterol
ITEMS | SPECIFICATION |
Melting point | 148-152&²Ô²ú²õ±è;¡ã°ä(±ô¾±³Ù.) |
InChIKey | UCTLRSWJYQTBFZ-DDPQNLDTSA-N |
alpha | -116 ? (C=1, CHCL3) |
storage temp. | -20¡ã°ä |
Merck | 13,2887 |
refractive index | 1.5100 (estimate) |
optical activity | [¦Á]20/D -115¡À8¡ã, c = 1% in chloroform |
EPA Substance Registry System | Cholesta-5,7-dien-3-ol, (3.beta.)- (434-16-2) |
Water Solubility | Insoluble |
density | 0.9717 (rough estimate) |
Boiling point | 451.27¡ãC (rough estimate) |
pka | 14.91¡À0.70(±Ê°ù±ð»å¾±³¦³Ù±ð»å) |
NIST Chemistry Reference | Cholesta-5,7-dien-3-ol, (3?beta?)-(434-16-2) |
BRN | 2224615 |
CAS DataBase Reference | 434-16-2(CAS DataBase Reference) |
| Standard Packaging | Bottles / Foil Bags / Cartons |
| Packaging Details | 50 mg / 100 mg / 1 g / 5 g |
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