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Name: Biphenyl dimethyl dicarboxylate  

CAS NO: 792-74-5

Purity: 99% min

MF: C16H14O4

MW:270.280

BP:407.0±38.0 °C at 760 mmHg

Density:1.2±0.1 g/cm3

MP: 213-215&苍产蝉辫;°颁(濒颈迟.)

EINECS:212-341-4

Appearance: White or off-white powder

Package: 25g, 100g, 500g, bulk package

Application:Pharmaceutical Intermediates

Other name:

Dimethyl biphenyl-4,4-dicarboxylate;

Dimethyl (1,1'-biphenyl)-4,4'-dicarboxylate;

(1,1'-Biphenyl)-4,4'-dicarboxylic acid, dimethyl ester;

methyl 4-(4-methoxycarbonylphenyl)benzoate;

4,4'-Biphenyldicarboxylic acid, dimethyl ester;

Dimethyl biphenyl-4,4'-dicarboxylate (biphenyl Dimethyl dicarboxylate) CAS NO: 792-74-5  is a liver protective agent extracted from schisandra fruit, which can induce ifn-related signal transduction.

Preparation and evaluation of biphenyl dimethyl dicarboxylate CAS NO: 792-74-5  microemulsions for oral delivery

To improve the solubility and bioavailability of poorly water-soluble biphenyl dimethyl dicarboxylate CAS NO: 792-74-5(BDD), a drug used in treating liver diseases, a premicroemulsion concentrate composed of oil, surfactant, and cosurfactant for oral administration of BDD was prepared, and its physicochemical properties and the pharmacokinetic parameters of BDD were evaluated. Among the non-ionic surfactants and oils studied, Tween 80, which led to the highest solubility of BDD (109.7 μg/ml), and Neobee M-5 were chosen for preparing a premicroemulsion concentrate. At the 2:1 ratio of Tween 80 to Neobee M-5 , the solubility of BDD increased 7-fold compared with that at the ratio of 1:4. The solubility of BDD was further improved by the addition of triacetin used as a cosurfactant. Droplet size of BDD microemulsion comprising Tween 80 and Neobee M-5 at the ratio of 2:1, and 35% of triacetin, was kept constant both in distilled water and artificial gastric fluid without pepsin (pH 1.2) throughout 120-min incubation period. BDD in premicroemulsion concentrate rapidly dissolved whereas the mixture of BDD and calcium-carboxymethylcellulose (Ca-CMC) (2:1) and BDD powder hardly dissolved during 120-min incubation. About 50% of BDD in premicroemulsion concentrate dissolved within 10 min. AUC 0 24 h and the mean maximum plasma level ( C max) of BDD after oral administration of premicroemulsion concentrate in rats were 5- and 9.8-fold higher, respectively, than those of BDD with Ca-CMC. These results demonstrate that premicroemulsion concentrate of BDD composed of Tween 80 and Neobee M-5 at the ratio of 2:1, and 35% of triacetin, greatly enhances the bioavailability of BDD after the dose, possibly due to the increase in solubility and immediate dispersion of drug in the gastrointestinal tract. Thus, this system may provide a useful dosage form for oral intake of a water-insoluble drug, BDD.

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