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Name:5-Fluoroorotic acid

CAS:703-95-7

MF:C5H3FN2O4

MW:174.09

EINECS:211-876-0

MP:278 °C

叠笔:143°颁

Density:1.61 ?

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Appearance:?White to Off-White Crystalline Solid

Purity:97%

Solubility:Chloroform, Methanol

Storage temp:Sealed in dry,Store in freezer, under -20°C

Package:5g, 10g,100g,bulk package

Other?name:

1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicaci;

1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicacid;

5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate;

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Application:

5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum.

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