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Molecular Formula: C20H10Na2O5
Molecular Weight: 376.27
EINECS: 208-253-0
Purity: 97% Min.
Package: 5 g / 25 g / 1 kg / 25 kg
Introduction of CAS: 518-47-8 Fluorescein Sodium
In examining subterranean waters. Serves to ascertain source of springs, connections between streams and sea, determining approx vol of water delivered by a spring, detecting source of contamination of drinking water, infiltration of soil with waste waters of factories. In externally applied drugs and cosmetics. Analytical reagent (protein label). Clinical reagent (immuno-histological stain, immuno-fluorescent label).
Brilliant yellow. Soluble in water and ethanol (with strong green fluorescent), water-soluble good. In strong sulfuric acid with weak for fluorescence yellow, it will be diluted with yellow precipitation. Its water solution and sodium hydroxide with dark green fluorescence for brunet solution. Mainly used for sea of target that fluorescent, facilitate aerial reconnaissance search. And can use significantly for the exploration of fluorescent groundwater. Can also be used for medicine and cosmetics shading, rarely used for silk printing and dyeing things.
ITEMS | SPECIFICATION |
Colour Index | 45350 |
Melting point | 320 ¡ãC |
InChIKey | NJDNXYGOVLYJHP-UHFFFAOYSA-L |
storage temp. | Store at +5¡ãC to +30¡ãC. |
solubility | H2O |
Merck | 14,4159 |
color | Rust-orange |
form | Powder |
EPA Substance Registry System | Fluorescein, disodium salt (518-47-8) |
¦Ë³¾²¹³æ | 491nm, 493.5nm, 490nm |
Water Solubility | 500 g/L (20 ?C) |
Stability | Stable. |
pka | 2.2, 4.4, 6.7(at 25¡æ) |
PH Range | Pink uorescence (4.0) to green uorescence (6.0) |
BRN | 3833041 |
PH | 8.3 (10g/l, H2O, 20¡æ) |
CAS DataBase Reference | 518-47-8(CAS DataBase Reference) |
Major Application | Nanolithography, nanoparticles, thin films, fuel cells, inks, laser, colored bubbles, cleansing products, identifying leaks in coolant, suntanning agent, hair dyes, cosmetics, dermatology, dental material, diagnosis of diabetic retinopathy, antitumor agent |
Odor | Odorless |
Yang, Vanessa Y.; Miller, Paul E.; Keys, Deborah A.; La Croix, Noelle C. [Veterinary Ophthalmology, 2021, vol. 24, # S1, p. 87 - 95]
Al-Mansour, Mazen R.; Caycedo-Marulanda, Antonio; Davis, Brian R.; Alawashez, Abdulrahim; Docimo, Salvatore; Qureshi, Alia; Tsuda, Shawn [Surgical Endoscopy, 2021, vol. 35, # 5, p. 2091 - 2103]
Production of CAS: 518-47-8 Fluorescein Sodium
Sodium fluorescein is generally obtained from the thermal condensation of resorcinol and phthalic anhydride to form a salt, and contains a large amount of impurities, mainly unreacted resorcinol, phenolphthalein and acridine yellow.
Application:
Sodium fluorescein is used as a fluorescent tracer to study the permeability of the blood brain barrier (BBB) and blood spinal cord barrier (BSCB) in rodent models. Using this dye as a probe substrate, the organic anion transporting polypeptide (OATP) mediated 365betÓéÀÖbook's hepatocyte drug transport was studied. Sodium fluorescein is also used to restore the in-situ solutes into the bone through fluorescence recovery after photofading. Fluorescein sodium salt is used as a solute to study microvascular permeability. It has been used as a test molecule to study the penetration of the blood barrier.
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